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Age-related differences in vitamin D status in Polish centenarians compared with 65-year-olds

Małgorzata Kupisz-Urbańska, Katarzyna Broczek, Krzysztof Galus, Małgorzata Mossakowska, Ewa Marcinowska-Suchowierska
Published online: June 24, 2020
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Abstract

Introduction: Vitamin D status is known to change with age; however, little is known about the vitamin D status in centenarians.

Objectives: The aim of the study was to assess vitamin D status and evaluate correlations among the levels of parathyroid hormone (PTH), 25-hydroxycholecalciferol (25(OH)D), 1,25-dihydroxycholecalciferol (1,25(OH)D), calcium (Ca), inorganic phosphorus (P) and alkaline phosphatase activity (ALP).

Patients and methods: The study group consisted of 97 subjects; 81 women and 16 men (median age 101.4 years). The centenarians were visited at their homes, where examinations were conducted and blood samples collected. The control group consisted of 57 subjects aged; 35 women and 22 men (median age 65.9 years). The concentrations of PTH, 25(OH)D, and 1,25(OH)D were measured from frozen plasma samples and Ca, P, and ALP from serum samples.

Results: The median Ca level was 8.88 mg/dl in centenarians and 9.52 mg/dl in 65-year-old subjects (p<0.01); ALP 223 IU vs. 190 IU (p=0.01); P 3.01 mg/dl vs. 3.23 mg/dl (p=0.13); PTH 45.59 pg/ml vs. 29.27 pg/ml (p<0.01); 25(OH)D 7.39 ng/ml vs. 19.81 ng/ml (p<0.01); 1,25(OH)D 57.5 pmol/l (19.13) vs. 78.6 pmol/l (p<0.01). Only the centenarians demonstrated correlations among the measured laboratory parameters.

Conclusions: Taking into account the lower 25(OH)D, 1,25(OH)D and Ca concentrations in the majority of centenarians, as well as the negative correlation between the vitamin D active metabolites and PTH, vitamin D and calcium supplementation should be systematically administered to the oldest of the elderly.

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