Acute myocardial infarction is still considered as one of the most threatening disorders in internal medicine. Numerous complications of infarction develop due to activation of different neurohumoral systems. The article discusses modern methods of pharmacological correction of neurohumoral system activity in various stages of myocardial infarction. It is emphasized that current guidelines do not always allow to effectively prevent left ventricular remodeling. New drugs used for this aim are discussed.