Anticardiolipin and anti-β2 glycoprotein-I antibodies patients with breast carcinoma: a pilot study

Introduction. Thrombosis – the main manifestation of antiphospholipid syndrome (APS) – is at the same time observed in some patients with malignancies. Objectives. Evaluation of prevalence of some antiphospholipid antibodies (aPL) in serum of patients with breast carcinoma and the possible correlation between aPL seropositivity and clinical symptoms. Patients and methods. 40 patients with breast carcinoma and 38 patients with non-malignant diseases of breast were studied. Anticardiolipin antibodies (aCL) and antibodies to β2 glycoprotein-I (anti-β2GPI) were detected by ELISA. Results. The aCL as well as anti-β2GPI were positive in 1 patient with breast carcinoma, who at the same time presented with symptoms of APS. In the control group 2 patients were positive for anti-β2GPI. Conclusions. We have not observed a difference of aPL prevalence between the group of patients with breast carcinoma and controls. The association of breast cancer and aPL seropositivity deserves further investigations.